PHARMACOLOGICAL ACTIONS OF O-BENZOYLTHIAMINE DISULFIDE

The role of the interchain disulfide bond in governing the pharmacological actions of botulinum toxin.

All serotypes of botulinum toxin possess a disulfide bond that links the heavy chain and light chain components of the holotoxin. Experiments were done to assess the functional significance of this covalent bond, and the work was facilitated by use of mercurial compounds that modify residues in the vicinity of the catalytic site. The data indicated that reduction of the interchain disulfide bon...

Pharmacological actions of cannabinoids.

Mammalian tissues express at least two types of cannabinoid receptor, CB1 and CB2, both G protein coupled. CB1 receptors are expressed predominantly at nerve terminals where they mediate inhibition of transmitter release. CB2 receptors are found mainly on immune cells, one of their roles being to modulate cytokine release. Endogenous ligands for these receptors (endocannabinoids) also exist. Th...

Some pharmacological actions of alcohol.

The contribution which alcohol may make to a man's nutrition varies considerably. Alcohol is not an essential dietary constituent, but it is commonly consumed, and unlike most foods it has notable subjective and objective effects in quantities which contribute trivially to the total daily calories. Moderate drinkers are much commoner than those who consume to excess, and it will therefore be mo...

The effect of various reducing compounds on the thiamine activity of S-benzoylthiamine O-monophosphate.

It has been shown in the previous paper (1) that S-benzoyl derivatives of thiamine, e. g., S-benzoylthiamine O-monophosphate (BTP) and S-benzoylthiamine (SBT), have seemingly thiamine activity on Lactobacillus ferinenti, but they are not active per se; it is due to the production of thiamine-active compounds by de-S-benzoyla tion. It seems to be of interest to clarify the mechanism of debenzoyl...

Jpet #58149 1 the Role of the Interchain Disulfide Bond in Governing the Pharmacological Actions of Botulinum Toxin**